Jessica de Rothschild was born on 5 June 1974. She belongs to the British branch of the Rothschild family descended from the banking dynasty established in London by Nathan Mayer Rothschild in the early nineteenth century.
Her father, Sir Evelyn de Rothschild, was one of the most prominent members of the family's British branch during the twentieth century. He led N M Rothschild & Sons and was involved in British finance, business and philanthropy.
Jessica's own career developed in a different direction. She became involved in journalism, theatre and film, including work as a literary editor for Tatler before moving further into production. Historical biographical records also identify her as having worked as a model.
Over time, her professional activities expanded beyond entertainment into philanthropy. She became particularly involved with the ERANDA Rothschild Foundation, which was established by her father and focuses on areas including education, healthcare and social welfare. She has served as a trustee since 2000.
Her humanitarian work subsequently became increasingly prominent. Since 2016, she has worked with the United Nations High Commissioner for Refugees (UNHCR). As of 2025, she was listed as Co-chair of the Women's Committee for USA for UNHCR and Co-chair of the UNHCR Global Women in Philanthropy Executive Committee.
She has therefore built a public profile around film, theatre, philanthropy, women's empowerment and humanitarian causes.